Description

2'-Amino-2'-Deoxy-5-Fluoro-Arabinouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for novel antiviral and anticancer therapeutics. It is primarily needed by research institutions, pharmaceutical companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of next-generation nucleoside-based drugs targeting viral infections and oncology.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antiviral and anticancer prodrugs.
• Antiviral Research: Investigated for activity against DNA viruses, including herpesviruses and hepatitis B virus (HBV).
• Oncology Research: Studied for its potential as a cytostatic agent in cancer chemotherapy protocols.
• Biochemical Tool: Used in enzymatic studies to investigate nucleoside metabolism and kinase activity.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Preclinical Development: Utilized in formulation studies and pharmacokinetic profiling of new chemical entities (NCEs).

Basic Information

Product Name	2'-Amino-2'-Deoxy-5-Fluoro-Arabinouridine
CAS No.	2305415-81-8
Molecular Formula	C9H12FN3O5
Molecular Weight	261.21 g/mol
Synonyms	5-Fluoro-2'-amino-2'-deoxyarabinouridine; 2'-Amino-2'-deoxy-5-fluorouridine; 2'-Amino-5-fluoro-2'-deoxyarabinouridine; 5-Fluoro-2'-amino-arabinouridine; 2'-NH2-5-F-AraU; 2'-Amino-5-fluoroarabinofuranosyluracil; 5-Fluoro-2'-amino-β-D-arabinofuranosyluracil; 2'-Amino-2'-deoxy-5-fluoro-β-D-arabinofuranosyluracil
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxy-5-Fluoro-Arabinouridine is manufactured under strict quality systems suitable for research and development use. We provide material with typical purity levels exceeding 95% (by HPLC), with higher grades available. All batches are supported by comprehensive analytical data, including HPLC chromatograms for purity and identity confirmation (NMR, MS). Certificates of Analysis (COA) detailing batch-specific results are available upon request to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.