Description

2-Aminomethyl Adenosine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the fields of oncology and antiviral drug discovery. Its unique structure, featuring an aminomethyl modification at the adenosine base, makes it a valuable intermediate for medicinal chemists and researchers in the life sciences sector. Key industries that utilize this high-purity intermediate include pharmaceutical R&D, biotechnology, and contract manufacturing organizations (CMOs) focused on next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Medicinal Chemistry Research: Used as a building block for structure-activity relationship (SAR) studies and the development of targeted therapies.
• Bioconjugation & Probe Development: The reactive aminomethyl group enables conjugation to fluorophores, affinity tags, or other molecules for creating biochemical probes.
• Enzyme Substrate Studies: Employed in biochemical assays to study the activity and inhibition of adenosine-processing enzymes like kinases and methyltransferases.
• Antisense Oligonucleotide (ASO) Research: Potential modified monomer for the development of advanced oligonucleotide therapeutics with enhanced properties.
• Chemical Biology Tool: Useful for investigating cellular signaling pathways involving adenosine receptors and related metabolic processes.

Basic Information

Product Name	2-Aminomethyl Adenosine
CAS No.	2305415-79-4
Molecular Formula	C11H15N7O4
Molecular Weight	309.28 g/mol
Synonyms	2-(Aminomethyl)adenosine; Adenosine, 2-(aminomethyl)-; 9-β-D-Ribofuranosyl-2-(aminomethyl)adenine; 2-AMA; 2-Aminomethyl-9-β-D-ribofuranosyladenine; N6-(aminomethyl)adenosine (tautomeric form); 2-(Aminomethyl)-9H-purin-6-amine riboside
EINECS	Contact for details

Quality Control

Every batch of 2-Aminomethyl Adenosine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (HPLC), purity, and identification. We adhere to cGMP principles for the production of advanced pharmaceutical intermediates, ensuring traceability and reliability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.