Description

4'-C-Methyl-2-Thiouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel oligonucleotides and therapeutic agents. It is primarily utilized by researchers and manufacturers in the fields of antiviral drug discovery, mRNA technology, and medicinal chemistry.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for introducing specific modifications into RNA strands to enhance stability and therapeutic efficacy.
• Antiviral Research: Investigated as a component in the development of nucleotide analogs targeting viral polymerases.
• Medicinal Chemistry: Serves as a versatile intermediate for structure-activity relationship (SAR) studies and the creation of novel bioactive molecules.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and function.
• Therapeutic mRNA Development: Incorporated into mRNA sequences to modulate immunogenicity and translation efficiency for vaccine and protein replacement therapy applications.
• Diagnostic Probe Development: Employed in the design of labeled probes for detecting specific RNA sequences.

Basic Information

Product Name	4'-C-Methyl-2-Thiouridine
CAS No.	2305415-74-9
Molecular Formula	C10H14N2O5S
Molecular Weight	274.29 g/mol
Synonyms	4'-C-Methyl-2-thiouridine; 2-Thio-4'-C-methyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-2-thioxo-1,2-dihydropyrimidin-4(3H)-one; 4'-Methyl-2-thiouridine; 2-Thiouridine, 4'-C-methyl-
EINECS	Contact for details

Quality Control

Our 4'-C-Methyl-2-Thiouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your research and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.