Description

5-n-Boc-Aminomethyluridine is a high-purity, protected nucleoside derivative essential for advanced oligonucleotide synthesis and pharmaceutical research. This compound serves as a critical building block for the site-specific introduction of functional groups into nucleic acid sequences, enabling the development of novel therapeutics and diagnostic probes. It is primarily utilized by researchers and manufacturers in the fields of antisense oligonucleotide (ASO) development, siRNA synthesis, and medicinal chemistry, where precise chemical modification is paramount.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Therapeutics: Enables the incorporation of stable, functionalized nucleosides to enhance target binding, nuclease resistance, and pharmacokinetic properties.
• Medicinal Chemistry & Drug Discovery: Used as an intermediate in the research and development of nucleoside-based antiviral and anticancer agents.
• Bioconjugation & Probe Development: The Boc-protected aminomethyl group provides a handle for subsequent conjugation with fluorescent dyes, affinity tags, or other bioactive molecules.
• Academic & Industrial Research: Fundamental reagent for studying nucleic acid structure, function, and for developing novel biotechnological tools.

Basic Information

Product Name	5-n-Boc-Aminomethyluridine
CAS No.	2305415-73-8
Molecular Formula	C15H23N3O8
Molecular Weight	373.36 g/mol
Synonyms	5-[(tert-Butoxycarbonylamino)methyl]uridine; 5-(Boc-aminomethyl)uridine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-[(2-methylpropan-2-yl)oxycarbonylaminomethyl]pyrimidine-2,4-dione; N-Boc-5-aminomethyluridine; 5-N-Boc-aminomethyluridine; Uridine, 5-[(tert-butoxycarbonylamino)methyl]-
EINECS	Contact for details

Quality Control

Our 5-n-Boc-Aminomethyluridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house specifications aligned with industry best practices for fine chemical and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label/COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.