Description

5-Azidomethyl-2'-β-Methyl Uridine is a high-purity, modified nucleoside building block of significant interest in advanced biochemical research and pharmaceutical development. This compound matters for its role as a key precursor in the synthesis of nucleotide analogs, enabling the study and development of novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in antiviral drug discovery, oligonucleotide synthesis, and the development of mRNA-based technologies.

Application

• Antiviral Drug Discovery: Serves as a critical intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral prodrugs.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support building block for introducing specific functionalities into DNA/RNA strands for research and therapeutic applications.
• Probe and Diagnostic Development: The azido group enables bioorthogonal "click chemistry" (e.g., CuAAC, SPAAC) for labeling, conjugation, and imaging studies.
• mRNA Technology Research: Investigated for incorporation into mRNA to study structure-function relationships and enhance stability or modulate immunogenicity.
• Medicinal Chemistry & SAR Studies: A valuable scaffold for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleotide analogs.
• Bioconjugation: Facilitates the site-specific attachment of reporter molecules, peptides, or other ligands to nucleic acids or related structures.

Basic Information

Product Name	5-Azidomethyl-2'-β-Methyl Uridine
CAS No.	2305415-72-7
Molecular Formula	C11H15N5O6
Molecular Weight	313.27 g/mol
Synonyms	2'-C-Methyl-5-azidomethyluridine; 5-(Azidomethyl)-2'-C-methyluridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-methyl-3-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(azidomethyl)pyrimidine-2,4(1H,3H)-dione; 2'-β-Methyl-5-azidomethyluridine; 5-Azidomethyl-2'-C-methyluridine; 5-N3Me-2'-C-Me-U; 2'-C-Me-5-N3Me-U
EINECS	Contact for details

Quality Control

Our 5-Azidomethyl-2'-β-Methyl Uridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with all applicable laboratory safety practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.