Description

Rac-(1R,2S)-2-(Difluoromethyl)Cyclopropane-1-Carboxylic Acid is a high-value, fluorinated cyclopropane derivative serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group on a strained cyclopropane ring, is engineered to modulate the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate fluorinated motifs for enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethylcyclopropyl moiety can improve lipophilicity and target binding.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorinated cyclopropanes on reaction kinetics, conformation, and molecular interactions.
• Material Science Precursor: Potential building block for specialty polymers and advanced materials requiring fluorinated components for specific thermal or chemical resistance properties.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	Rac-(1R,2S)-2-(Difluoromethyl)Cyclopropane-1-Carboxylic Acid
CAS No.	2278284-80-1
Molecular Formula	C5H6F2O2
Molecular Weight	136.10 g/mol
Synonyms	(±)-(1R,2S)-2-(Difluoromethyl)cyclopropanecarboxylic Acid; rac-(1R,2S)-2-(Difluoromethyl)cyclopropanecarboxylic Acid; 2-(Difluoromethyl)cyclopropane-1-carboxylic Acid (racemic mixture of diastereomers); DL-2-(Difluoromethyl)cyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 2-(difluoromethyl)-, (1R,2S)-rel-; (1R,2S)-rel-2-(Difluoromethyl)cyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of Rac-(1R,2S)-2-(Difluoromethyl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and diastereomeric ratio meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its carboxylic acid nature and sensitivity to strong bases/fluoride, keep away from incompatible materials such as strong alkalis and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Diastereomeric Ratio (HPLC)	≥ 95:5 (1R,2S : other diastereomers)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.