Description

Pomalidomide-Peg3-N3 is a high-purity, synthetic chemical building block designed for advanced pharmaceutical research and development. This compound is critical for the creation of antibody-drug conjugates (ADCs) and targeted therapeutics through bioorthogonal click chemistry. It is primarily utilized by medicinal chemists and bioconjugation specialists in pharmaceutical, biotechnology, and academic research institutions. The product, identified by CAS number 2267306-15-8, enables precise drug targeting and payload delivery.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a key intermediate for constructing ADCs, where the PEG spacer enhances solubility and the azide group enables site-specific conjugation to antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Proteolysis-Targeting Chimera (PROTAC) Development: Used as a component in the design of heterobifunctional molecules that recruit E3 ubiquitin ligases to degrade target proteins.
• Targeted Drug Delivery Systems: Facilitates the development of novel drug delivery platforms by conjugating the pomalidomide moiety to targeting vectors like peptides, proteins, or nanoparticles.
• Chemical Biology and Probe Development: Acts as a versatile tool for labeling and studying cereblon (CRBN) E3 ubiquitin ligase and its substrates in cellular environments.
• Preclinical Pharmaceutical Research: Employed in the discovery and optimization stages of new molecular entities, particularly in oncology and immunology.
• Bioconjugation and Protein Engineering: Enables the site-specific modification of biomolecules for therapeutic, diagnostic, or imaging applications.

Basic Information

Product Name	Pomalidomide-Peg3-N3
CAS No.	2267306-15-8
Molecular Formula	C24H31N7O7
Molecular Weight	529.55 g/mol
Synonyms	Pomalidomide-PEG3-azide; 4-((2-(2-(2-Azidoethoxy)ethoxy)ethoxy)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Pomalidomide-PEG3-N3; Pomalidomide-triethyleneglycol-azide; CRBN Ligand-PEG3-N3; (S)-Pomalidomide-PEG3-N3; Azido-PEG3-Pomalidomide; 1,3-Dioxo-2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]methyl]-1H-isoindole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to strict quality management protocols to ensure supply reliability and product consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.