Description

Pimicotinib is a potent and selective small molecule inhibitor targeting specific kinase pathways involved in cellular signaling. This compound is of significant interest for its potential therapeutic applications in oncology and inflammatory disease research. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions engaged in drug discovery and preclinical studies.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the development of novel kinase inhibitor therapies.
• Oncology Drug Discovery: Used in in vitro and in vivo studies to investigate its efficacy against specific cancer cell lines and tumor models.
• Biochemical Assays: Employed as a tool compound to study kinase function, signal transduction pathways, and mechanism of action.
• Preclinical Studies: Essential for pharmacokinetics (PK), pharmacodynamics (PD), and toxicology evaluations during the drug candidate selection process.
• Academic Research: Supports fundamental biological research into cellular proliferation, apoptosis, and immune response modulation.
• Process Chemistry & Scale-up: Used as a benchmark in the development and optimization of synthetic routes for API manufacturing.

Basic Information

Product Name	Pimicotinib
CAS No.	2253123-16-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ABBV-399; Pimicotinib (ABBV-399); (S)-N-(5-((2-(2,6-dichloro-3,5-dimethoxyphenyl)amino)pyrimidin-4-yl)-4-methyl-1,3-thiazol-2-yl)pyrrolidine-1-carboxamide; UNII-1R4F6E8O6T
EINECS	Contact for details

Quality Control

Our Pimicotinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling using advanced techniques such as HPLC, NMR, and MS. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.