Description

Amg 510 CAS NO 2252403-56-6 is a potent and selective small molecule inhibitor targeting the KRAS G12C mutant protein, a key oncogenic driver in several cancers. This compound represents a significant advancement in targeted cancer therapy, offering a direct approach to inhibiting a previously "undruggable" target. It is primarily utilized by pharmaceutical research organizations, biotechnology companies, and academic institutions engaged in oncology drug discovery and development.

Application

• Oncology Research & Drug Discovery: Primary application as a research tool and lead compound for developing novel anti-cancer therapeutics targeting KRAS G12C mutations.
• Biochemical & Cellular Assays: Used in in vitro studies to investigate KRAS G12C signaling pathways, mechanism of action, and downstream effects.
• Preclinical Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical pharmacokinetic, pharmacodynamic, and toxicology studies.
• Combination Therapy Studies: Investigated in research settings for potential synergistic effects when combined with other targeted agents, immunotherapies, or chemotherapies.
• Resistance Mechanism Analysis: Employed to study and understand the development of resistance to KRAS G12C inhibition in cancer cell lines and models.

Basic Information

Product Name	Amg 510
CAS No.	2252403-56-6
Molecular Formula	C30H30F2N6O3
Molecular Weight	560.60 g/mol
Synonyms	Sotorasib; AMG-510; Lumakras; (R)-1-((2-Chloro-6-fluorophenyl)methyl)-7-fluoro-6-(1-methyl-6-((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)-4-oxo-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid; ARS-1620 analog; KRAS G12C inhibitor; KRAS(G12C) inhibitor
EINECS	Contact for details

Quality Control

Our Amg 510 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.