Description

1(2H)-Pyridineethanol, α-(2,4-Difluorophenyl)-3,6-Dihydro-β,4-Dimethyl-α-(1H-1,2,4-Triazol-1-Ylmethyl)-, (αr,βr)- is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture designed for targeted synthesis. This compound matters because it serves as a critical building block in the development of novel active pharmaceutical ingredients (APIs), particularly in antifungal and other therapeutic areas. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to ensure the integrity and efficacy of their final drug products, enabling innovation in global healthcare.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel triazole-containing antifungal agents and other specialized APIs.
• Antifungal Drug Development: Core structural component for research and production of next-generation systemic antifungal medications targeting fungal CYP51.
• Organic Synthesis Research: Used in academic and industrial laboratories for method development and exploring new chemical entities (NCEs) with complex stereochemistry.
• Preclinical & Clinical Trial Material: Supplied under GMP guidelines for the production of batches intended for toxicology studies and clinical trials.
• Agrochemical Intermediate: Potential application in the synthesis of advanced crop protection agents leveraging its difluorophenyl and triazole motifs.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for optimizing synthetic routes from lab to pilot and commercial scale.

Basic Information

Product Name	1(2H)-Pyridineethanol, α-(2,4-Difluorophenyl)-3,6-Dihydro-β,4-Dimethyl-α-(1H-1,2,4-Triazol-1-Ylmethyl)-, (αr,βr)-
CAS No.	2252350-12-0
Molecular Formula	C19H23F2N5O
Molecular Weight	375.42 g/mol
Synonyms	(αR,βR)-α-(2,4-Difluorophenyl)-β,4-dimethyl-α-(1H-1,2,4-triazol-1-ylmethyl)-3,6-dihydro-1(2H)-pyridineethanol; (2R,3R)-2-(2,4-Difluorophenyl)-3-methyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1,2,3,6-tetrahydropyridin-2-ylethanol; VT-1161 Intermediate; Oteseconazole Intermediate; Difluorophenyl Triazolylmethyl Dihydropyridineethanol; (R,R)-Fosravuconazole Intermediate; (αR,βR)-Fosravuconazole Key Chiral Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, GC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support audits and regulatory documentation for cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.