Description

(2R,3R)-3-((1H-1,2,4-Triazol-1-Yl)Methyl)-6-Fluoro-3-Hydroxy-2-Methyl-4''-Methylenespiro[Indoline-1,1''-Piperidin]-1-Ium Fluoride is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of targeted antifungal and other therapeutic agents. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of complex, high-value molecules. The precise stereochemistry and functional groups make it a key building block for modern drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel antifungal APIs and other specialized therapeutics.
• Antifungal Drug Development: A key structural component for research into new triazole-based antifungal agents targeting fungal cell membrane synthesis.
• Organic Synthesis Building Block: Used in academic and industrial research for constructing complex spirocyclic and heterocyclic molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Process Chemistry & Scale-Up: Supports process development and optimization for the commercial manufacturing of target drug substances.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(2R,3R)-3-((1H-1,2,4-Triazol-1-Yl)Methyl)-6-Fluoro-3-Hydroxy-2-Methyl-4''-Methylenespiro[Indoline-1,1''-Piperidin]-1-Ium Fluoride
CAS No.	2252350-11-9
Molecular Formula	C18H22F2N4O
Molecular Weight	348.39 g/mol
Synonyms	6-Fluoro-3-hydroxy-2-methyl-3-[(1H-1,2,4-triazol-1-yl)methyl]-4-methylenespiro[indoline-1,1'-piperidin]-1-ium fluoride; (2R,3R)-3-(1H-1,2,4-Triazol-1-ylmethyl)-6-fluoro-3-hydroxy-2-methyl-4-methylenespiro[indoline-1,1'-piperidin]-1-ium fluoride; Spiro[indoline-1,1'-piperidin]-1-ium fluoride derivative; Fluoride salt of triazole-spiroindolinepiperidine; CAS 2252350-11-9; Advanced antifungal intermediate
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-((1H-1,2,4-Triazol-1-Yl)Methyl)-6-Fluoro-3-Hydroxy-2-Methyl-4''-Methylenespiro[Indoline-1,1''-Piperidin]-1-Ium Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles for advanced intermediates to ensure consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and potential degradation. Store away from incompatible materials such as strong bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.