Description

N2-iso-Butyroyl-7’-o-(4,4’-Dimethoxytrityloxy)Morpholinoguanine is a sophisticated, high-purity nucleoside phosphoramidite derivative, a critical building block in the automated synthesis of oligonucleotides. This compound matters because it provides the essential guanine base with specific protecting groups, enabling precise and efficient DNA/RNA sequence construction for research and therapeutic development. It is primarily needed by biotechnology and pharmaceutical companies engaged in antisense therapy, siRNA development, and diagnostic probe manufacturing, where sequence fidelity and yield are paramount.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer in solid-phase synthesizers for constructing custom DNA and RNA strands.
• Therapeutic Oligonucleotide Production: Manufacturing active pharmaceutical ingredients (APIs) for antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) therapies.
• Diagnostic Probe Development: Synthesis of labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH) applications.
• Research & Development: Academic and industrial R&D for studying gene function, gene silencing, and nucleic acid interactions.
• Synthetic Biology: Building blocks for creating novel genetic circuits and engineered biological systems.
• Next-Generation Sequencing (NGS): Used in the preparation of specialized oligonucleotide libraries and adapters.

Basic Information

Product Name	N2-iso-Butyroyl-7’-o-(4,4’-Dimethoxytrityloxy)Morpholinoguanine
CAS No.	2243974-78-7
Molecular Formula	C45H49N6O8
Molecular Weight	801.92 g/mol
Synonyms	7'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-deoxy-7-deazaguanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 7-Deaza-dG(Ibu) Phosphoramidite, DMT protected; N2-Isobutyryl-7-deaza-2'-deoxyguanosine-3'-CE phosphoramidite; c7dG(Ibu) Phosphoramidite; 7-Deaza-2'-deoxyguanosine, N2-isobutyryl-, 5'-[bis(4-methoxyphenyl)phenylmethyl] 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Morpholino guanine phosphoramidite derivative; c7-G(Ibu) Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of N2-iso-Butyroyl-7’-o-(4,4’-Dimethoxytrityloxy)Morpholinoguanine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for oligonucleotide synthesis. Our products are characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98.5% by HPLC), moisture content, and other critical parameters is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.