Description

Idh1 Inhibitor 1 CAS NO 2234285-81-3 is a potent and selective small molecule inhibitor of the Isocitrate Dehydrogenase 1 (IDH1) enzyme, a key target in oncology research. This compound is crucial for investigating the role of mutant IDH1 in tumor metabolism and epigenetic dysregulation, offering significant potential for therapeutic development. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer metabolism, hematologic malignancies, and solid tumor research.

Application

• Biochemical Research: Used as a critical tool compound for in vitro studies to elucidate the mechanistic role of mutant IDH1 in cellular transformation and the production of the oncometabolite 2-hydroxyglutarate (2-HG).
• Drug Discovery & Development: Serves as a reference standard and lead compound in high-throughput screening (HTS) campaigns and structure-activity relationship (SAR) studies for novel oncology therapeutics.
• Preclinical Studies: Employed in cell-based assays and animal models to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of IDH1 inhibition for potential cancer treatment.
• Target Validation: Essential for validating IDH1 as a therapeutic target in various cancer types, including gliomas, acute myeloid leukemia (AML), and chondrosarcomas.
• Epigenetics Research: Applied in studies investigating the link between altered metabolism and changes in histone and DNA methylation patterns driven by mutant IDH1 activity.

Basic Information

Product Name	Idh1 Inhibitor 1
CAS No.	2234285-81-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	IDH1 Inhibitor 1; IDH1 Inhibitor; Isocitrate Dehydrogenase 1 Inhibitor; AGI-5198; AGI 5198; AGI5198; (R)-2-((1-(4-Chlorophenyl)ethyl)amino)-N-((1-(2-chlorophenyl)cyclopropyl)methyl)benzamide; Enasidenib analog; Research compound for IDH1 mutation.
EINECS	Contact for details

Quality Control

Our Idh1 Inhibitor 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and NMR/MS for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.