Description

Arv-471 is a high-purity, small molecule pharmaceutical intermediate of significant interest in modern therapeutic development. This compound is crucial for research and development efforts targeting specific disease pathways, offering a key building block for advanced active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in preclinical and clinical-stage drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel investigational drugs and active pharmaceutical ingredients (APIs).
• Proteolysis-Targeting Chimera (PROTAC) Research: A key component in the development of targeted protein degradation therapies, a cutting-edge modality in oncology and other disease areas.
• Oncology Drug Discovery: Used in R&D for potential cancer therapeutics, particularly those focusing on hormone receptor pathways.
• Biochemical Research: Employed as a reference standard and tool compound in biochemical assays and mechanism-of-action studies.
• Preclinical Development: Supports formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and safety assessment in animal models.

Basic Information

Product Name	Arv-471
CAS No.	2229711-08-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ARV-471; Vepdegestrant; (3S)-3-[4-[(1S)-1-[2-(2-Chloro-4-hydroxyphenyl)-1,1-difluoroethyl]-2,5-dioxopyrrolidin-3-yl]phenyl]-5,5-difluoro-1,3-diazinane-2,4,6-trione; PF-07850327; ARV 471
EINECS	Contact for details

Quality Control

Our Arv-471 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.