Description

2,2-Difluoro-2-(4-(Trifluoromethoxy)Phenyl)Ethanol is a high-value fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoroethanol and trifluoromethoxy substituents, makes it a critical intermediate for introducing fluorine motifs into target molecules, which can dramatically alter their physicochemical and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas, where fluorination is a common strategy to optimize ADME properties.
• Agrochemical Synthesis: Used to construct advanced fluorinated herbicides, fungicides, and insecticides, leveraging fluorine's ability to increase biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, where its structure can influence dielectric anisotropy and thermal stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty fluoropolymers with unique surface properties, chemical resistance, and optical clarity.
• Organic Synthesis & Catalysis Research: A valuable reagent for methodological studies in fluorination chemistry and asymmetric synthesis in academic and industrial R&D laboratories.
• Positron Emission Tomography (PET) Tracer Development: Potential use in the synthesis of fluorinated radiotracers for medical imaging, given the presence of fluorine atoms amenable to isotopic labeling.

Basic Information

Product Name	2,2-Difluoro-2-(4-(Trifluoromethoxy)Phenyl)Ethanol
CAS No.	2229220-36-2
Molecular Formula	C9H7F5O2
Molecular Weight	242.14 g/mol
Synonyms	2,2-Difluoro-2-[4-(trifluoromethoxy)phenyl]ethanol; 4-(Trifluoromethoxy)benzeneethanol, 2,2-difluoro-; 2,2-Difluoro-2-(4-trifluoromethoxyphenyl)ethanol; 1-(4-(Trifluoromethoxy)phenyl)-2,2-difluoroethan-1-ol; α,α-Difluoro-4-(trifluoromethoxy)benzeneethanol; 2,2-Difluoro-1-(4-(trifluoromethoxy)phenyl)ethan-1-ol
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-(4-(Trifluoromethoxy)Phenyl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where required, and we support our clients with the necessary documentation for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place, ideally at controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent evaporation and potential moisture uptake. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.