Description

3-(Azido-Peg5-Amino)Propanol CAS NO 2228857-31-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a terminal amino group, separated by a flexible PEG5 spacer and a propanol linker. This compound is a critical building block for bioconjugation and click chemistry applications, enabling the efficient, site-specific coupling of biomolecules, polymers, and surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for developing advanced drug delivery systems, diagnostic probes, and functionalized biomaterials.

Application

• Bioconjugation Linker: For coupling peptides, proteins, antibodies, or oligonucleotides to other molecules, nanoparticles, or solid supports via copper-free or strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry.
• PEGylation Reagent: To introduce hydrophilic PEG spacers onto drug molecules or therapeutic proteins, improving solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization: For modifying gold nanoparticles, quantum dots, glass slides, or polymer surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• Crosslinking Agent: In the synthesis of hydrogels, polymer networks, and dendrimers where controlled, bio-orthogonal crosslinking is required.
• Probe Synthesis: As a precursor for creating fluorescent, radioactive, or affinity tags for imaging, diagnostics, and target identification.
• ADC Development: In the design and synthesis of antibody-drug conjugates (ADCs), providing a cleavable or non-cleavable linker between the antibody and the cytotoxic payload.

Basic Information

Product Name	3-(Azido-Peg5-Amino)Propanol
CAS No.	2228857-31-4
Molecular Formula	C18H38N4O7
Molecular Weight	422.52 g/mol
Synonyms	3-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propylamine; Azido-PEG5-amine propanol; N3-PEG5-NH2 propanol; 3-(Azido-pentaethylene glycol-amino)propanol; Azido-PEG5-AP; Heterobifunctional PEG azide-amine; 1-Amino-3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propane; PEG-based azide amine linker
EINECS	Contact for details

Quality Control

Our 3-(Azido-Peg5-Amino)Propanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and functional group integrity as verified by NMR, HPLC, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90%
Functional Group Assay (Amine)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.