Description

2-(4-Bromo-3-Methoxyphenyl)-2,2-Difluoroethan-1-Ol is a high-purity fluorinated aromatic building block designed for advanced organic synthesis. This compound is valued for its unique difluoroethanol moiety attached to a bromo-methoxy substituted benzene ring, which serves as a versatile intermediate in the development of complex molecules. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the difluoro and bromo substituents can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct more complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on the physical and chemical properties of organic molecules in academic and industrial R&D settings.
• Peptidomimetic & Bioisostere Development: The difluoroethanol group can act as a bioisostere for phosphate or carboxylate groups in the design of enzyme inhibitors and peptide mimics.

Basic Information

Product Name	2-(4-Bromo-3-Methoxyphenyl)-2,2-Difluoroethan-1-Ol
CAS No.	2228656-15-1
Molecular Formula	C9H9BrF2O2
Molecular Weight	267.07 g/mol
Synonyms	2-(4-Bromo-3-methoxyphenyl)-2,2-difluoroethanol; 1-(4-Bromo-3-methoxyphenyl)-2,2-difluoroethan-1-ol; 4-Bromo-3-methoxy-α,α-difluorobenzeneethanol; 2,2-Difluoro-2-(4-bromo-3-methoxyphenyl)ethanol; (4-Bromo-3-methoxyphenyl)difluoromethyl carbinol
EINECS	Contact for details

Quality Control

Our 2-(4-Bromo-3-Methoxyphenyl)-2,2-Difluoroethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.