Description

2,2-Difluoro-2-(3,5-Difluorophenyl)Ethanol is a specialized fluorinated alcohol building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoroethanol moiety and the electron-deficient difluorophenyl ring, making it a critical intermediate for constructing complex molecules. This compound is primarily needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly where fluorine substitution is used to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorine atoms enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and fluorinated materials with unique surface properties.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands and organocatalysts for asymmetric synthesis, leveraging the steric and electronic influence of the fluorinated groups.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination methodologies and the effects of polyfluorination on molecular conformation and reactivity.
• Diagnostic Agent Synthesis: Potential intermediate in the development of contrast agents or radiotracers for medical imaging (e.g., PET).

Basic Information

Product Name	2,2-Difluoro-2-(3,5-Difluorophenyl)Ethanol
CAS No.	2228216-34-8
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	2-(3,5-Difluorophenyl)-2,2-difluoroethanol; 3,5-Difluoro-α,α-difluorobenzeneethanol; 2,2-Difluoro-2-(3,5-difluorophenyl)ethan-1-ol; (3,5-Difluorophenyl)difluoromethyl carbinol; α,α-Difluoro-3,5-difluorobenzeneethanol
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-(3,5-Difluorophenyl)Ethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.