Description

Loxo-292 is a high-purity, small molecule pharmaceutical intermediate or active ingredient, identified by CAS NO 2222755-14-6. This compound is critical for research and development in targeted cancer therapies, offering a key building block for novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology and precision medicine.

Application

• Pharmaceutical R&D: Serves as a key intermediate in the synthesis of investigational new drugs (INDs) for targeted cancer therapy.
• Preclinical Studies: Used in the formulation of drug candidates for in vitro and in vivo efficacy and toxicity testing.
• Biochemical Research: Employed as a reference standard or tool compound in enzymatic assays and target validation studies.
• Process Chemistry: Acts as a starting material or advanced intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing processes.
• Academic Research: Utilized in university and institutional labs for studying specific biological pathways and mechanisms of action.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials.

Basic Information

Product Name	Loxo-292
CAS No.	2222755-14-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LOXO-292; Selpercatinib Intermediate; RET Kinase Inhibitor Intermediate; 2222755-14-6; (S)-N-(6-(6-Amino-5-((2-(dimethylamino)ethyl)amino)pyrazin-2-yl)pyridin-3-yl)-3-fluoro-2,6-dimethylbenzamide (possible structure); LOXO292; RET Inhibitor LOXO-292.
EINECS	Contact for details

Quality Control

Our Loxo-292 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities to meet the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.