Description

1-(α-L-Threofuranosyl)Cytosine is a synthetic nucleoside analog with a modified sugar moiety. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a building block in the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of nucleoside-based drugs and oligonucleotide synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Oligonucleotide Synthesis: Serves as a modified building block (phosphoramidite) for the solid-phase synthesis of therapeutic oligonucleotides, such as antisense or siRNA molecules.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new therapeutic agents with improved efficacy and reduced toxicity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1-(α-L-Threofuranosyl)Cytosine
CAS No.	2166199-20-6
Molecular Formula	C8H11N3O5
Molecular Weight	229.19 g/mol
Synonyms	L-Threofuranosylcytosine; 1-((2S,3S)-3,4-Dihydroxy-2-(hydroxymethyl)butyl)cytosine; α-L-Threofuranosylcytosine; Cytosine, 1-(α-L-threofuranosyl)-; 4-Amino-1-((2S,3S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrofuran-1-yl)pyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 1-(α-L-Threofuranosyl)Cytosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.