Description

Kras G12C Inhibitor 5 CAS NO 2158297-63-1 is a potent and selective small molecule inhibitor targeting the KRAS G12C mutant protein, a key oncogenic driver in various cancers. This compound is crucial for advancing oncology research and the development of targeted cancer therapies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on precision medicine and novel oncology drug discovery.

Application

• Oncology Research & Drug Discovery: A critical tool compound for studying KRAS G12C signaling pathways and validating drug targets in cancer biology.
• Preclinical Development: Used in in vitro and in vivo studies to assess efficacy, pharmacokinetics, and pharmacodynamics of KRAS G12C inhibition.
• Biochemical Assays: Serves as a reference standard and positive control in high-throughput screening (HTS) and enzymatic inhibition assays.
• Mechanism of Action Studies: Enables detailed investigation into the covalent binding mechanism and downstream effects of KRAS G12C inhibition.
• Combination Therapy Research: Explored in studies evaluating synergistic effects with other targeted agents or immunotherapies.
• Chemical Probe Development: Acts as a starting point or benchmark for medicinal chemistry efforts to develop next-generation KRAS inhibitors.

Basic Information

Product Name	Kras G12C Inhibitor 5
CAS No.	2158297-63-1
Molecular Formula	C30H30F2N8O3
Molecular Weight	588.61 g/mol
Synonyms	KRAS G12C Inhibitor 5; (S)-1-((S)-3-(4-Acryloylpiperazin-1-yl)-1-((1r,4S)-4-(2-(2,6-difluorophenyl)pyrimidin-4-yl)cyclohexyl)-1-oxopropan-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxamide; MRTX-5; ARS-1620 analog; G12C mutant KRAS inhibitor 5; KRASG12C inhibitor 5
EINECS	Contact for details

Quality Control

Our Kras G12C Inhibitor 5 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR and MS structural confirmation, and determination of residual solvents and moisture content. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.