Description

N3-Peg12-Ch2Ch2Cooh is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide (N3) group and a carboxylic acid (COOH) terminus, separated by a 12-unit PEG spacer. This compound is essential for creating stable, water-soluble conjugates in bioconjugation and materials science, enabling precise "click chemistry" coupling with alkynes. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries for developing antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized nanoparticles.

Application

• Bioconjugation reagent for synthesizing antibody-drug conjugates (ADCs) and protein-polymer hybrids.
• Functional linker in the development of PEGylated therapeutics to enhance solubility and pharmacokinetics.
• Surface modification agent for nanoparticles and quantum dots to impart biocompatibility and targeting capabilities.
• Key intermediate in click chemistry applications for creating hydrogels and biomaterials.
• Crosslinking agent for modifying peptides, oligonucleotides, and other biomolecules.
• Tool compound in diagnostic assay development for creating stable detection probes.

Basic Information

Product Name	N3-Peg12-Ch2Ch2Cooh
CAS No.	2152679-71-3
Molecular Formula	C31H59N3O15
Molecular Weight	713.8 g/mol
Synonyms	Azido-PEG12-acid; N3-PEG12-COOH; 15-Azido-4,7,10,13-tetraoxa-3-aza-1-pentadecanoic acid; Azido-dodecaethylene glycol-acetic acid; Azido-PEG12-acetic acid; Heterobifunctional PEG linker, Azide-Acid; PEG-based crosslinker, N3-PEG-COOH
EINECS	Contact for details

Quality Control

Our N3-Peg12-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with research and cGMP-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, Water, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.