Description

Loxo-292 CAS NO 2152628-33-4 is a high-purity, small molecule pharmaceutical intermediate and research chemical of significant interest in modern drug discovery. This compound is a critical building block for the development of targeted cancer therapies, particularly those focused on specific genetic mutations. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in oncology and precision medicine.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel targeted oncology therapeutics.
• Biochemical Research: Used as a reference standard and active agent in cellular and enzymatic assays for cancer research.
• Drug Discovery & Development: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate pharmacokinetics and efficacy of candidate drug molecules.
• Chemical Biology: A tool compound for probing specific biological pathways and protein functions.
• API Synthesis: Intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for clinical trials.

Basic Information

Product Name	Loxo-292
CAS No.	2152628-33-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LOXO-292; Selpercatinib Intermediate; RET Kinase Inhibitor Intermediate; (S)-N-((6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl)methyl)-2-(4-(4-methyl-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)piperazin-1-yl)acetamide; BLU-667 Intermediate; Retevmo Intermediate
EINECS	Contact for details

Quality Control

Our Loxo-292 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.