Description

1-((2S,5R)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One Malonate is a high-purity, advanced pharmaceutical intermediate designed for targeted drug discovery and development. This compound is critical for medicinal chemistry research, particularly in the synthesis of kinase inhibitors and other small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Preclinical Drug Development: Serves as a critical precursor in the scale-up synthesis of candidate drug molecules for toxicology and pharmacology studies.
• Bioconjugation & Probe Development: The prop-2-en-1-one (acrylamide) moiety can be utilized for selective covalent binding or probe labeling in chemical biology.
• Custom Synthesis: Supplied to contract research organizations (CROs) and contract development and manufacturing organizations (CDMOs) for client-specific projects.
• Academic Research: Used in university and institutional labs for fundamental research in chemical biology and drug discovery mechanisms.

Basic Information

Product Name	1-((2S,5R)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One Malonate
CAS No.	2140301-97-7
Molecular Formula	C19H23N5O5
Molecular Weight	401.42 g/mol
Synonyms	(2S,5R)-1-Acryloyl-2-methyl-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-ium malonate; 1-[(2S,5R)-5-[(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino]-2-methyl-1-piperidinyl]-2-propen-1-one malonate; Acrylamide-pyrrolopyrimidine-piperidine malonate salt; Kinase inhibitor intermediate 2140301-97-7
EINECS	Contact for details

Quality Control

Our 1-((2S,5R)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One Malonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.