Description

Cdk4/6-In-4 CAS NO 2138499-06-4 is a potent and selective small-molecule inhibitor targeting the cyclin-dependent kinases 4 and 6 (CDK4/6), key regulators of the cell cycle. This compound is a critical research tool for investigating cell proliferation mechanisms and developing novel therapeutic strategies in oncology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer biology and drug discovery.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific roles and signaling pathways of CDK4 and CDK6 in cell cycle progression.
• Oncology Drug Discovery: Serves as a reference compound or a lead molecule in high-throughput screening and structure-activity relationship (SAR) studies for developing new anticancer agents.
• Mechanistic Studies: Employed in vitro and in vivo to elucidate the mechanisms of cell cycle dysregulation in various cancer types, including breast cancer, glioblastoma, and leukemia.
• Preclinical Development: Used in animal models to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of CDK4/6 inhibition as a therapeutic approach.
• Cell Culture & Assay Development: A key reagent for establishing and validating cellular assays that measure proliferation, senescence, or drug sensitivity.

Basic Information

Product Name	Cdk4/6-In-4
CAS No.	2138499-06-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CDK4/6 Inhibitor-4; Cdk4/6-In-4; CAS 2138499-06-4; CDK4/6-IN-4; CDK4/6 inhibitor 4; 2138499-06-4; CDK4/6 Inhibitor IV; (Chemical name to be confirmed)
EINECS	Contact for details

Quality Control

Our Cdk4/6-In-4 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.