Description

Ropsacitinib is a potent and selective small molecule inhibitor of Janus kinase 1 (JAK1), representing a significant advancement in targeted immunomodulatory therapy. This high-purity active pharmaceutical ingredient (API) is critical for pharmaceutical research and development, enabling the creation of novel treatments for inflammatory and autoimmune conditions. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery and preclinical studies.

Application

• Pharmaceutical R&D: Core active ingredient for the development of new JAK1 inhibitor-based therapeutics.
• Autoimmune Disease Research: Investigation into treatments for conditions such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease (IBD).
• Dermatology Drug Development: Targeted research for atopic dermatitis and other chronic skin inflammation disorders.
• Preclinical & Clinical Trial Material: Sourcing of high-quality API for non-clinical safety studies and formulation of clinical trial supplies.
• Mechanistic Biology Studies: Tool compound for elucidating the JAK-STAT signaling pathway in cellular and biochemical assays.
• Reference Standard: Serves as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Item	Details
Product Name	Ropsacitinib
CAS No.	2127109-84-4
Molecular Formula	C₂₀H₂₃N₅O₂
Molecular Weight	365.43 g/mol
Synonyms	PF-07038124; Ropsacitinib (PF-07038124); (S)-N-(4-(1H-Pyrazol-4-yl)phenyl)-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)piperidin-1-yl)propanamide; PF07038124; PF 07038124; Ropsacitinibum; UNII-2K8Y8QJ9VJ
EINECS	Contact for details

Quality Control

Our Ropsacitinib is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical research. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F), in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.