Description

1-Piperidineethanol, α-(2,4-Difluorophenyl)-β-Methyl-4-Methylene-α-(4H-1,2,4-Triazol-4-Ylmethyl)-, (αr,βr)- is a sophisticated chiral piperidine derivative, a key intermediate in modern pharmaceutical synthesis. This compound is valued for its complex molecular architecture, which incorporates a difluorophenyl group and a 1,2,4-triazole moiety, making it a critical building block for active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring high-purity, structurally advanced intermediates.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of advanced drug candidates, particularly in central nervous system (CNS) and antifungal therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Used as a building block in the research and process development of new APIs, leveraging its triazole and fluorinated aromatic functionalities.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating libraries of bioactive compounds.
• Process Chemistry: Acts as a key material in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	1-Piperidineethanol, α-(2,4-Difluorophenyl)-β-Methyl-4-Methylene-α-(4H-1,2,4-Triazol-4-Ylmethyl)-, (αr,βr)-
CAS No.	2122222-10-8
Molecular Formula	C18H23F2N3O
Molecular Weight	335.40 g/mol
Synonyms	(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-[(4H-1,2,4-triazol-4-yl)methyl]-1-piperidineethanol; (Ar,Br)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(4H-1,2,4-triazol-4-ylmethyl)-1-piperidineethanol; Difluorophenyl Triazolylmethyl Piperidineethanol; CAS 2122222-10-8; Pharmaceutical Intermediate 2122222-10-8; Chiral Piperidine-Triazole Derivative
EINECS	Contact for details

Quality Control

Our 1-Piperidineethanol derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (αR,βR)
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.