Description

Asciminib Hydrochloride is a highly selective, allosteric inhibitor of the BCR-ABL1 tyrosine kinase, representing a novel therapeutic mechanism of action. This specificity is critical for overcoming resistance and intolerance associated with ATP-competitive inhibitors in targeted cancer therapy. It is primarily required by pharmaceutical research organizations and manufacturers developing advanced treatments for chronic myeloid leukemia (CML).

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in the formulation of targeted oncology drugs.
• Biomedical Research: Used as a critical reference standard and tool compound in preclinical studies for BCR-ABL1 driven cancers.
• Mechanism of Action Studies: Facilitates research into allosteric inhibition pathways and resistance mechanisms in kinase biology.
• Drug Development: Employed in the synthesis and process development of next-generation tyrosine kinase inhibitor (TKI) therapies.
• Analytical Method Development: Acts as a primary standard for establishing HPLC, LC-MS, and other analytical protocols for quality control.

Basic Information

Product Name	Asciminib Hydrochloride
CAS No.	2119669-71-3
Molecular Formula	C23H27Cl2FN6O • HCl
Molecular Weight	517.86 g/mol
Synonyms	ABL001 Hydrochloride; Asciminib HCl; (S)-N-[4-(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide Hydrochloride; ABL 001 hydrochloride; Scemblix (brand name reference); Allosteric BCR-ABL1 inhibitor; STAMP inhibitor
EINECS	Contact for details

Quality Control

Our Asciminib Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.