Description

Propanoic Acid, 3-[2-[2-[[2-(2-Cyclooctyn-1-Yloxy)Acetyl]Amino]Ethoxy]Ethoxy]-, 2,3,4,5,6-Pentafluorophenyl Ester is a specialized bifunctional chemical reagent designed for advanced bioconjugation and labeling applications. This compound matters because it combines a highly reactive strained alkyne (cyclooctyne) with an activated pentafluorophenyl (PFP) ester, enabling rapid, catalyst-free "click chemistry" ligations with azides under mild, physiological conditions. It is primarily needed by researchers and developers in pharmaceutical discovery, proteomics, and materials science for creating stable, well-defined molecular constructs.

Application

• Bioorthogonal Labeling: Site-specific labeling of proteins, antibodies, and other biomolecules modified with azide functional groups.
• Chemical Proteomics: As a key reagent in activity-based protein profiling (ABPP) and target identification studies.
• ADC Development: Facilitating the construction of antibody-drug conjugates (ADCs) through controlled linker-drug attachment.
• Polymer & Materials Functionalization: Modifying surfaces, nanoparticles, and hydrogels with bioactive ligands for diagnostic and therapeutic platforms.
• Fluorescent Probe Synthesis: Conjugation of azide-containing fluorophores or other reporter molecules to cyclooctyne-tagged targets.
• Glycan Imaging & Analysis: Labeling metabolically incorporated azido-sugars for visualization and study of cellular glycans.

Basic Information

Product Name	Propanoic Acid, 3-[2-[2-[[2-(2-Cyclooctyn-1-Yloxy)Acetyl]Amino]Ethoxy]Ethoxy]-, 2,3,4,5,6-Pentafluorophenyl Ester
CAS No.	2101206-61-3
Molecular Formula	C25H28F5NO6
Molecular Weight	533.49 g/mol
Synonyms	PFP-PEG3-BCN Ester; BCN-PEG3-PFP; 2,3,4,5,6-Pentafluorophenyl 3-[2-[2-[[2-(2-Cyclooctyn-1-yloxy)acetyl]amino]ethoxy]ethoxy]propanoate; Bicyclo[6.1.0]nonyne-PEG3-PFP Ester; BCN-PEG3-PFP Ester; Pentafluorophenyl ester of BCN-PEG3-acid; DBCO-PEG3-PFP Ester (common misnomer); BCN-PEG(3)-PFP
EINECS	Contact for details

Quality Control

Our Propanoic Acid, 3-[2-[2-[[2-(2-Cyclooctyn-1-Yloxy)Acetyl]Amino]Ethoxy]Ethoxy]-, 2,3,4,5,6-Pentafluorophenyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and performance consistency suitable for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR or functional assay)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.