Description

Zotatifin is a potent and selective small molecule inhibitor of eukaryotic translation initiation factor 4A (eIF4A), a key component of the eIF4F complex. This compound matters for its critical role in disrupting cap-dependent mRNA translation, a process often dysregulated in cancer and other proliferative diseases. Researchers and pharmaceutical developers in the fields of oncology, virology, and molecular biology need it for advanced preclinical studies and as a tool compound to investigate protein synthesis pathways.

Application

• Oncology Research: Investigation of eIF4A-dependent oncogene translation and evaluation as a potential anti-cancer therapeutic agent.
• Virology Studies: Research into host-directed antiviral strategies by targeting the cellular translation machinery required for viral replication.
• Molecular Biology Tool: Used as a selective chemical probe to study the role of eIF4A and the eIF4F complex in cap-dependent translation initiation.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies.
• Biochemical Assays: Utilized in in vitro translation assays and mechanistic studies to understand translational control.

Basic Information

Product Name	Zotatifin
CAS No.	2098191-53-6
Molecular Formula	C₂₈H₂₈N₄O₄
Molecular Weight	484.55 g/mol
Synonyms	eFT226; Zotatifin (eFT226); (S)-2-(4-(4-(2-(3,5-Dimethylisoxazol-4-yl)ethyl)piperazin-1-yl)phenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine-5-carboxamide; ABBV-744 (Note: Verify specific compound); eIF4A Inhibitor eFT226; Translation Initiation Inhibitor eFT226
EINECS	Contact for details

Quality Control

Our Zotatifin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and all relevant specifications is provided to ensure it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.