Description

3'-Azido-3'-Deoxy-5-Fluoro-β-L-Cytidine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of nucleoside-based prodrugs and active pharmaceutical ingredients (APIs). The precise modification of the cytidine scaffold with azido and fluoro groups imparts unique biochemical properties, making it a valuable tool for probing biological mechanisms and creating targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of investigational antiviral and anticancer drugs.
• Antiviral Research: Used in the development of nucleoside analogs targeting RNA viruses, including potential treatments for hepatitis C and other viral infections.
• Oncology Drug Discovery: Serves as a building block for creating chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Probe: Utilized in metabolic pathway studies and enzyme inhibition assays due to its modified sugar and base moieties.
• Prodrug Synthesis: Acts as a core structure for designing prodrugs with improved bioavailability and targeted delivery.
• Academic & Contract Research: Essential for universities and CROs conducting cutting-edge medicinal chemistry and pharmacology research.

Basic Information

Product Name	3'-Azido-3'-Deoxy-5-Fluoro-β-L-Cytidine
CAS No.	2095417-76-6
Molecular Formula	C9H11FN6O4
Molecular Weight	286.22 g/mol
Synonyms	3'-Azido-3'-deoxy-5-fluoro-L-cytidine; 5-Fluoro-3'-azido-3'-deoxy-L-cytidine; 3'-Azido-5-fluoro-3'-deoxy-L-cytidine; 3'-N3-5-F-L-Cytidine; β-L-3'-Azido-3'-deoxy-5-fluorocytidine; 1-((2R,3S,5R)-3-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-1,2-dihydropyrimidin-2-one; 5-Fluoro-1-((2R,3S,5R)-3-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-5-Fluoro-β-L-Cytidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected by the pharmaceutical industry for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.