Description

3'-Azido-3'-Deoxy-5-Methoxyuridine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer prodrugs, leveraging its unique azido functionality for bioorthogonal click chemistry applications. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of next-generation antiviral agents, particularly for targeting RNA viruses.
• Prodrug Development: Used to create masked nucleoside analogs designed for targeted drug delivery and activation.
• Bioconjugation & Labeling: The azido group enables efficient, site-specific conjugation with alkyne-bearing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for creating labeled probes.
• Anticancer Research: Investigated as a component in compounds designed to inhibit cancer cell proliferation by interfering with DNA/RNA synthesis.
• Chemical Biology Tool: Employed in studying nucleoside metabolism and incorporation mechanisms within cells.
• Nucleoside Library Synthesis: A valuable scaffold for generating diverse libraries of modified nucleosides for high-throughput screening.

Basic Information

Product Name	3'-Azido-3'-Deoxy-5-Methoxyuridine
CAS No.	2095417-70-0
Molecular Formula	C10H13N5O6
Molecular Weight	299.24 g/mol
Synonyms	3'-Azido-3'-deoxy-5-methoxyuridine; 5-Methoxy-3'-azido-3'-deoxyuridine; 3'-Azido-5-methoxy-2',3'-dideoxyuridine; 3'-N3-5-MeO-dU; AZT-Methoxyuridine analog; 1-((2R,4S,5R)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methoxypyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Every batch of 3'-Azido-3'-Deoxy-5-Methoxyuridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We adhere to high-purity standards suitable for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (IR, NMR), and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.