Description

5-Benzylaminocarbonyl-3'-o-Acetyl-2'-o-Methyluridine is a chemically modified nucleoside derivative, specifically engineered for advanced pharmaceutical research and development. This compound is a critical building block in the synthesis of oligonucleotides, enabling the creation of novel therapeutic agents with enhanced stability and biological activity. It is primarily utilized by research institutions and pharmaceutical companies focused on antisense oligonucleotide (ASO) development, siRNA therapeutics, and mRNA technology platforms.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase synthesis of modified oligonucleotides for therapeutic applications.
• Antisense Oligonucleotide (ASO) Research: Used to incorporate specific modifications that enhance nuclease resistance and target affinity in ASO drug candidates.
• siRNA and miRNA Therapeutics: Serves as a modified monomer to improve the pharmacokinetic profile and potency of RNA interference-based drugs.
• mRNA Vaccine and Therapeutic Development: Employed in research to develop modified mRNA with improved translational efficiency and reduced immunogenicity.
• Diagnostic Probe Synthesis: Utilized in creating labeled nucleic acid probes for sensitive detection and diagnostic assays.
• Medicinal Chemistry & Drug Discovery: Acts as a versatile scaffold for structure-activity relationship (SAR) studies in nucleoside-based drug discovery programs.

Basic Information

Product Name	5-Benzylaminocarbonyl-3'-o-Acetyl-2'-o-Methyluridine
CAS No.	2095417-64-2
Molecular Formula	C20H23N3O8
Molecular Weight	433.41 g/mol
Synonyms	5-(Benzylaminocarbonyl)-3'-O-acetyl-2'-O-methyluridine; 2'-O-Methyl-3'-O-acetyl-5-carbamoylbenzyluridine; 5-[(Benzylamino)carbonyl]-3'-O-acetyl-2'-O-methyluridine; N-Benzyl-5-uridinecarboxamide, 3'-acetate 2'-methyl ether; 2'-O-Methyl-3'-O-acetyl-5-(N-benzylcarbamoyl)uridine; 5-(Benzylcarbamoyl)-2'-O-methyl-3'-O-acetyluridine; Modified Uridine Monomer; BzAm-C-3'Ac-2'OMe-U
EINECS	Contact for details

Quality Control

Our 5-Benzylaminocarbonyl-3'-o-Acetyl-2'-o-Methyluridine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.