Description

3'-Azido-3'-Deoxy-5-Trifluoromethyluridine is a modified nucleoside analog that integrates azido and trifluoromethyl functional groups, offering unique reactivity and physicochemical properties for advanced research and development. This compound is a critical building block in medicinal chemistry, particularly for the synthesis of novel antiviral and anticancer agents, leveraging its structural modifications to enhance binding affinity and metabolic stability. It is primarily sought by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on nucleoside-based drug discovery and probe development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel antiviral and anticancer nucleoside analogs.
• Probe Development: Utilized in bioorthogonal chemistry (e.g., click chemistry) due to the reactive azido group for labeling and studying biological systems.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Bioconjugation: The azide functionality enables conjugation with alkyne-bearing molecules for creating targeted drug conjugates or diagnostic agents.
• Chemical Biology Tool: Used to investigate metabolic pathways and enzyme mechanisms involving nucleotide processing.
• Process Chemistry: Employed in the scale-up synthesis of active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	3'-Azido-3'-Deoxy-5-Trifluoromethyluridine
CAS No.	2095417-62-0
Molecular Formula	C10H9F3N4O5
Molecular Weight	322.20 g/mol
Synonyms	3'-Azido-3'-deoxy-5-(trifluoromethyl)uridine; 5-Trifluoromethyl-3'-azido-3'-deoxyuridine; 3'-N3-3'-dU-5-CF3; 3'-Azido-5-trifluoromethyl-2',3'-dideoxyuridine; 1-((2R,3S,5R)-3-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione; AZT-CF3 Uridine Derivative
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-5-Trifluoromethyluridine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. A detailed Certificate of Analysis (COA) is provided, documenting all specifications and test results. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.