Description

N6-Benzoyl-2'-Chloro-2'-Deoxyadenosine is a chemically modified nucleoside analog, serving as a crucial building block and key intermediate in advanced pharmaceutical synthesis. Its value lies in enabling the precise construction of oligonucleotide sequences, particularly for antisense and siRNA therapeutic applications. This high-purity intermediate is essential for research institutions and manufacturers developing next-generation nucleic acid-based drugs and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modified oligonucleotides, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).
• Antiviral Drug Research: Used in the development of nucleoside analog prodrugs targeting viral polymerases.
• Oncology Therapeutics: Intermediate for creating targeted cancer therapies that utilize gene silencing mechanisms.
• Diagnostic Probe Synthesis: Employed in the manufacture of labeled probes for genetic testing and molecular diagnostics.
• Biochemical Research: Tool compound for studying nucleic acid chemistry, enzyme kinetics, and polymerase interactions.
• Process Development: Serves as a reference standard and starting material for scaling up GMP-grade oligonucleotide production.

Basic Information

Product Name	N6-Benzoyl-2'-Chloro-2'-Deoxyadenosine
CAS No.	2095417-58-4
Molecular Formula	C17H16ClN5O4
Molecular Weight	389.80 g/mol
Synonyms	2'-Chloro-2'-deoxy-N6-benzoyladenosine; 2'-Cl-2'-dA(Bz); 2'-Chloro-N6-benzoyl-2'-deoxyadenosine; 9-[(2R,3S,4R,5R)-5-(Chloromethyl)-3,4-dihydroxytetrahydrofuran-2-yl]-N-phenyl-9H-purin-6-amine; Bz-2'-Cl-dA; N6-Bz-2'-chloro-2'-deoxyadenosine; 2'-Chloro-2'-deoxyadenosine N6-benzoyl protected monomer
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-2'-Chloro-2'-Deoxyadenosine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC purity and identity confirmation (NMR, MS). We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.