Description

N2-iso-Butyroyl-2'-o-Propargylguanosine is a chemically modified nucleoside derivative, specifically engineered for advanced research and development applications. This compound is a critical building block in the synthesis of oligonucleotides, enabling precise structural modifications for enhanced stability and functionality. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, antisense therapy, and diagnostic probe synthesis, where high-purity, specialized nucleosides are essential.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense and siRNA Therapeutics: Used to incorporate propargyl modifications that can enhance nuclease resistance and cellular uptake of therapeutic oligonucleotides.
• Diagnostic Probe Development: Serves as a modified base for creating labeled probes used in fluorescence in situ hybridization (FISH) and other detection assays.
• Click Chemistry Conjugation: The propargyl group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for attaching reporter molecules, peptides, or other functional groups.
• Structural Biology Studies: Employed to investigate nucleic acid structure, function, and protein-nucleic acid interactions through site-specific labeling.
• Apitamer Discovery (SELEX): Used to introduce unique functional groups into nucleic acid libraries to expand chemical diversity and binding capabilities.

Basic Information

Product Name	N2-iso-Butyroyl-2'-o-Propargylguanosine
CAS No.	2095417-55-1
Molecular Formula	C17H21N5O6
Molecular Weight	391.38 g/mol
Synonyms	2'-O-Propargyl-N2-isobutyrylguanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)oxolan-2-yl]-2-(2-methylpropanoylamino)-1H-purin-6-one; Isobutyryl-Propargyl-Guanosine; N2-Isobutyryl-2'-O-propargylguanosine; 2'-O-Propargyl-N2-isobutyryl-guanosine; Propargyl Modified Guanosine; Guanosine, N2-isobutyryl-2'-O-propargyl-
EINECS	Contact for details

Quality Control

Our N2-iso-Butyroyl-2'-o-Propargylguanosine is manufactured under strict quality systems to ensure batch-to-batch consistency for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-process controls and final release testing protocols to meet the exacting standards required for pharmaceutical intermediates and advanced biochemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.