Description

5-Hydroxymethyl-2'-o-(2-Methoxyethyl)Uridine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical and biotechnology research. This compound is valued for its role as a key building block in the synthesis of oligonucleotides, particularly for therapeutic applications. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel antisense oligonucleotides, siRNA, and mRNA-based therapeutics. The precise modification it offers is critical for enhancing the stability, specificity, and pharmacokinetic properties of next-generation nucleic acid drugs.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of therapeutic oligonucleotides.
• Antisense Therapy Development: Used in research and production of antisense oligonucleotides (ASOs) designed to target specific RNA sequences.
• siRNA and miRNA Therapeutics: Serves as a modified monomer to introduce stability against nucleases in small interfering RNA (siRNA) and microRNA (miRNA) constructs.
• mRNA Technology: Employed in the research of modified messenger RNA (mRNA) for vaccines and protein replacement therapies.
• Diagnostic Probe Development: Utilized in creating labeled probes for genetic testing and molecular diagnostics.
• Biochemical Research: Acts as a tool compound for studying RNA structure, function, and protein-RNA interactions.

Basic Information

Product Name	5-Hydroxymethyl-2'-o-(2-Methoxyethyl)Uridine
CAS No.	2095417-51-7
Molecular Formula	C13H20N2O8
Molecular Weight	332.31 g/mol
Synonyms	2'-O-Methoxyethyl-5-hydroxymethyluridine; 5-Hydroxymethyl-2'-O-(2-methoxyethyl)uridine; 5-HM-2'-MOE-Uridine; 2'-MOE-5-HM-U; Uridine, 5-(hydroxymethyl)-2'-O-(2-methoxyethyl)-; 5-(Hydroxymethyl)-2'-O-(2-methoxyethyl)uridine; 2'-O-(2-Methoxyethyl)-5-(hydroxymethyl)uridine; MOE-5-HM-U
EINECS	Contact for details

Quality Control

Our 5-Hydroxymethyl-2'-o-(2-Methoxyethyl)Uridine is manufactured under strict quality systems suitable for research and pharmaceutical development. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting our commitment to supplying high-purity building blocks for critical therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.