Description

5-Furan-2-Yl-2'-o-Methyl-5'-o-Dmt-Uridine is a sophisticated, protected nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis. This compound is a critical building block in the production of modified RNA and DNA strands, offering precise control over molecular structure and function. It is essential for researchers and manufacturers in the fields of therapeutic oligonucleotide development, antisense technology, and diagnostic probe synthesis.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of modified RNA sequences.
• Antisense Oligonucleotide (ASO) Manufacturing: Used to incorporate specific modifications that enhance stability, target affinity, and pharmacokinetic properties of therapeutic ASOs.
• siRNA and miRNA Research: Enables the site-specific introduction of chemical modifications to study gene silencing mechanisms and improve therapeutic candidate efficacy.
• Diagnostic Probe Development: Serves as a modified base in the construction of high-specificity probes for molecular diagnostics and bioanalytical assays.
• Medicinal Chemistry & Drug Discovery: A valuable intermediate for exploring novel nucleoside-based therapeutics and prodrugs.
• Academic & Institutional Research: Supports fundamental studies in nucleic acid chemistry, biochemistry, and molecular biology.

Basic Information

Product Name	5-Furan-2-Yl-2'-o-Methyl-5'-o-Dmt-Uridine
CAS No.	2095417-47-1
Molecular Formula	C35H34N2O9
Molecular Weight	626.66 g/mol
Synonyms	2'-O-Methyl-5-(2-furyl)-5'-O-(4,4'-dimethoxytrityl)uridine; 5-(2-Furyl)-2'-O-methyl-5'-O-DMT-uridine; 5-(2-Furanyl)-2'-O-methyl-5'-O-(4,4'-dimethoxytrityl)uridine; DMT-2'-O-Me-5-furyl-Uridine; 2'-O-Methyl-5-furyl-5'-O-DMT-uridine; 5-Furyl-2'-O-methyl-5'-O-DMT-uridine; Protected 5-Furyl-2'-O-Methyluridine
EINECS	Contact for details

Quality Control

Our production of this high-purity nucleoside intermediate adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and consistency suitable for cGMP-compliant pharmaceutical applications. Comprehensive analytical data, including HPLC purity and spectroscopic confirmation (NMR, MS), is documented. A detailed Certificate of Analysis (COA) is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.