Description

5'-Azido-5'-Deoxy-2'-o-(2-Methoxyethyl)-5-Methyluridine is a chemically modified nucleoside analog, a critical building block for advanced oligonucleotide synthesis. This compound matters for its role in creating stable, nuclease-resistant antisense oligonucleotides and siRNA therapeutics, enabling precise genetic targeting. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and CROs focused on developing next-generation nucleic acid-based therapies and diagnostic probes.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite precursor for constructing therapeutic oligonucleotides with enhanced metabolic stability.
• siRNA and miRNA Development: Used to introduce modifications that improve silencing activity and pharmacokinetic profiles of RNAi therapeutics.
• Click Chemistry Conjugation: The 5'-azido group enables efficient, site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling or attaching payloads.
• Prodrug and Bioconjugate Platforms: Serves as a versatile linker for creating targeted drug delivery systems in medicinal chemistry.
• Nucleic Acid Research: A valuable tool for academic and industrial research into nucleic acid structure, function, and chemical biology.
• Diagnostic Probe Fabrication: Used in the development of sensitive and specific probes for genomic detection and analysis.

Basic Information

Item	Detail
Product Name	5'-Azido-5'-Deoxy-2'-o-(2-Methoxyethyl)-5-Methyluridine
CAS No.	2095417-42-6
Molecular Formula	C13H19N5O7
Molecular Weight	357.32 g/mol
Synonyms	5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine; 5-Methyl-2'-O-(2-methoxyethyl)-5'-azido-5'-deoxyuridine; 5'-N3-5'-d-2'-MOE-5-Me-uridine; 2'-MOE-5-methyluridine-5'-azide; Azido-MOE-5-methyluridine; 5'-Azido-2'-O-methoxyethyl-5-methyluridine; 2095417-42-6
EINECS	Contact for details

Quality Control

Our 5'-Azido-5'-Deoxy-2'-o-(2-Methoxyethyl)-5-Methyluridine is manufactured under strict quality management systems suitable for research and pharmaceutical development. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and decomposition. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.