Description

N2-(Isopropylphenoxyacetyl)-2'-o-Propargylguanosine is a chemically modified nucleoside derivative, specifically a propargylated guanosine analog. This compound is of significant value in pharmaceutical research and development, particularly as a key intermediate or building block for the synthesis of novel therapeutic agents. It is primarily needed by research institutions, pharmaceutical companies, and biotechnology firms engaged in the development of antiviral drugs, oligonucleotide therapeutics, and targeted molecular probes. Its unique structure allows for further functionalization via click chemistry, making it a versatile tool for advanced medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for research, diagnostics, and therapeutic applications (e.g., antisense, siRNA).
• Click Chemistry Substrate: The propargyl group enables efficient, site-specific conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and bioconjugation.
• Biochemical Research: Serves as a probe or tool compound for studying nucleic acid metabolism, enzyme inhibition, and cellular processes.
• Precision Medicine Development: A component in the creation of targeted drug delivery systems and personalized therapeutic modalities.
• Academic & Industrial R&D: Fundamental research material in medicinal chemistry and chemical biology for exploring new drug candidates.

Basic Information

Product Name	N2-(Isopropylphenoxyacetyl)-2'-o-Propargylguanosine
CAS No.	2095417-23-3
Molecular Formula	C20H23N5O6
Molecular Weight	429.43 g/mol
Synonyms	2'-O-Propargyl-N2-(isopropylphenoxyacetyl)guanosine; N2-(4-Isopropylphenoxyacetyl)-2'-O-propargylguanosine; 2'-O-Propargylguanosine N2-(isopropylphenoxyacetate); Propargyl Guanosine Derivative; Isopropylphenoxyacetyl Guanosine Propargyl Ether; Guanosine, N2-[(4-isopropylphenoxy)acetyl]-2'-O-2-propyn-1-yl-; Research Grade Modified Nucleoside
EINECS	Contact for details

Quality Control

Our N2-(Isopropylphenoxyacetyl)-2'-o-Propargylguanosine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate manufacturing. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.