Description

2'-Azido-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-5-Methyluridine is a sophisticated, protected nucleoside derivative designed for advanced oligonucleotide synthesis. This compound is a critical building block for the creation of modified nucleic acids, enabling the development of next-generation therapeutic and diagnostic agents. It is primarily utilized by research institutions and pharmaceutical companies specializing in antisense oligonucleotides, siRNA, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of azide-modified DNA and RNA strands.
• Antisense & RNAi Therapeutics: Enables the site-specific incorporation of functional handles (via click chemistry) into oligonucleotides for targeted drug delivery and conjugation.
• Diagnostic Probe Development: Used to create labeled nucleic acid probes for advanced detection and imaging applications in research and diagnostics.
• Bioconjugation & Click Chemistry: The azido group serves as a bioorthogonal handle for efficient conjugation with alkynes, facilitating the attachment of fluorophores, peptides, or other molecules.
• Structural Biology Studies: Incorporation into nucleic acids to study structure-function relationships and biomolecular interactions.
• Materials Science: Foundation for creating functionalized nucleic acid nanomaterials and aptamers.

Basic Information

Product Name	2'-Azido-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-5-Methyluridine
CAS No.	2095417-08-4
Molecular Formula	C31H31N5O7
Molecular Weight	585.61 g/mol
Synonyms	5-Methyl-2'-azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine; 2'-Azido-5-methyl-2'-deoxy-5'-O-DMT-uridine; 5-Methyl-2'-azido-2'-deoxyuridine 5'-O-DMT ether; DMT-2'-N3-5-Methyluridine; Azido-DMT-5-Methyluridine; 2'-Azido-5-methyluridine DMT protected; N3-2'-dU(Me) DMT
EINECS	Contact for details

Quality Control

Every batch of 2'-Azido-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-5-Methyluridine is manufactured and tested under strict quality management systems. We guarantee high purity and consistency suitable for sensitive pharmaceutical and research applications. Comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation, is provided with each Certificate of Analysis (COA) available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This material is strictly light-sensitive and hygroscopic; prolonged exposure to light, air, or moisture will lead to decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.