Description

5-Naphthyl-β-Methylaminocarbony-3'-o-Acetyl-2'-o-Methl-5'-o-Dmtr-Uridine is a sophisticated, protected nucleoside derivative designed for advanced oligonucleotide synthesis. This compound matters because it serves as a critical building block for the creation of modified RNA and DNA sequences, enabling research into gene function, therapeutic development, and diagnostic applications. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense technology, siRNA, and aptamer development.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite precursor for introducing specific modifications into synthetic oligonucleotides.
• Antisense & siRNA Therapeutic Research: For constructing research-grade oligonucleotides targeting specific mRNA sequences for gene silencing studies.
• Aptamer Development: In the synthesis of nucleic acid libraries and specific aptamers for diagnostic and therapeutic targeting.
• Structural Biology Studies: To incorporate modified bases for probing RNA/DNA structure, function, and protein-nucleic acid interactions.
• Diagnostic Probe Synthesis: Manufacturing labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Chemical Biology Tool Development: Creating cross-linking agents or affinity tags based on modified nucleosides for mechanistic studies.

Basic Information

Product Name	5-Naphthyl-β-Methylaminocarbony-3'-o-Acetyl-2'-o-Methl-5'-o-Dmtr-Uridine
CAS No.	2095417-00-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5-(1-Naphthyl)-N-methylcarbamoyl-3'-O-acetyl-2'-O-methyl-5'-O-(4,4'-dimethoxytrityl)uridine; 5-(Naphthalen-1-yl)-N-methylcarboxamido-2'-O-methyl-5'-O-DMTr-uridine 3'-acetate; DMTr-Protected 5-Modified 2'-O-Methyluridine Derivative; 5-(1-Naphthylcarbamoyl methyl)-2'-O-methyluridine 3'-acetate 5'-DMTr ether; N1-Methyl-5-(1-naphthoyl)uridine Derivative; 2'-O-Me-5-(1-Nap)-Uridine Phosphoramidite Precursor
EINECS	Contact for details

Quality Control

Our 5-Naphthyl-β-Methylaminocarbony-3'-o-Acetyl-2'-o-Methl-5'-o-Dmtr-Uridine is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.