Description

Arq-531 is a potent and selective small molecule inhibitor primarily targeting Bruton's tyrosine kinase (BTK) and other kinases within the TEC family. This compound is a critical research tool for investigating B-cell receptor signaling pathways and their role in oncology and immunology. It is essential for pharmaceutical R&D, academic research, and preclinical studies focused on developing novel therapeutics for hematological malignancies and autoimmune disorders.

Application

• Biochemical Research: Used as a high-purity reference standard and active pharmaceutical ingredient (API) in kinase inhibition assays and signaling pathway studies.
• Oncology Drug Discovery: Serves as a key intermediate or lead compound in the development of targeted therapies for B-cell cancers such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL).
• Immunology Studies: Employed to elucidate the role of BTK in autoimmune and inflammatory diseases, aiding in the discovery of new immunomodulators.
• Preclinical Development: Utilized in in vitro and in vivo models to assess pharmacokinetics, pharmacodynamics, and efficacy profiles.
• High-Throughput Screening (HTS): Acts as a control compound in screening campaigns to identify novel kinase inhibitors.

Basic Information

Product Name	Arq-531
CAS No.	2095393-15-8
Molecular Formula	C₂₉H₂₈N₈O₂
Molecular Weight	520.59 g/mol
Synonyms	ARQ 531; ARQ-531; BMS-986177; (S)-5-(2-(1H-Pyrazolo[3,4-b]pyridin-5-yl)ethyl)-N-(5-(4-methyl-1,4-diazepan-1-yl)pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-7-carboxamide; Reversible BTK Inhibitor ARQ-531; BDTX-4933
EINECS	Contact for details

Quality Control

Our Arq-531 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the material should be handled in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.