Description

(R)-5-(2-Fluoro-4-(2-Oxo-5-((Phosphonooxy)Methyl)Oxazolidin- 3-Yl)Phenyl)-2-(2-Methyl-2H-Tetrazol-5-Yl)Pyridine 1-Oxide is a sophisticated, high-purity chiral intermediate of significant importance in modern pharmaceutical development. Its complex molecular architecture, featuring a fluorinated phenyl ring, an oxazolidinone core, and a tetrazole-pyridine N-oxide system, makes it a critical building block for targeted drug synthesis. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the discovery and production of novel antibacterial agents, particularly next-generation oxazolidinone-class antibiotics. Its precise stereochemistry and functional groups are essential for achieving desired biological activity and pharmacokinetic profiles in final Active Pharmaceutical Ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research-scale and commercial synthesis of novel oxazolidinone antibiotics, such as advanced analogs of linezolid and tedizolid.
• Antibacterial Drug Discovery: Serves as a core structural motif in medicinal chemistry programs aimed at developing new agents against drug-resistant Gram-positive bacteria, including MRSA and VRE.
• API Manufacturing: Used as a critical intermediate in the multi-step GMP-compliant production of complex antibiotic Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) and mechanism of action of bacterial protein synthesis inhibitors.
• Process Chemistry Development: Utilized for optimizing synthetic routes, scaling up production, and developing robust, cost-effective manufacturing processes for new chemical entities (NCEs).

Basic Information

Item	Details
Product Name	(R)-5-(2-Fluoro-4-(2-Oxo-5-((Phosphonooxy)Methyl)Oxazolidin- 3-Yl)Phenyl)-2-(2-Methyl-2H-Tetrazol-5-Yl)Pyridine 1-Oxide
CAS No.	2095200-68-1
Molecular Formula	C20H17FN6O7P
Molecular Weight	503.36 g/mol
Synonyms	(R)-Tedizolid Phosphate Intermediate; (R)-TR-700 FA Intermediate; (R)-5-(2-Fluoro-4-(2-oxo-5-((phosphonooxy)methyl)oxazolidin-3-yl)phenyl)-2-(2-methyl-2H-tetrazol-5-yl)pyridine 1-oxide; (R)-TR-700 Phosphate Precursor; (R)-Tedizolid Phosphate Key Chiral Building Block; (R)-DA-7157 Related Compound; Oxazolidinone Antibiotic Intermediate (R-form); (R)-3-(4-(2-(2-Methyl-2H-tetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-((phosphonooxy)methyl)oxazolidin-2-one
EINECS	Contact for details

Quality Control

Our production of this high-value pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and purity suitable for advanced research and GMP manufacturing. Each lot is characterized using advanced analytical techniques including HPLC, chiral HPLC, 1H/13C/19F/31P NMR, and mass spectrometry to confirm identity, enantiomeric excess (typically >99.0%), and impurity profile. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Maximum Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.