Description

Protac Bet Degrader-2 is a potent and selective bifunctional degrader molecule designed for targeted protein degradation research. This compound is a critical tool for investigating the BET family of bromodomain proteins and their roles in epigenetic regulation and disease pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, immunology, and chemical biology for drug discovery and target validation studies.

Application

• Targeted Protein Degradation Research: A key chemical probe for studying PROTAC (Proteolysis Targeting Chimera) technology and the ubiquitin-proteasome system.
• Epigenetics and Oncology Studies: Used to investigate the biological functions and therapeutic potential of degrading BET proteins (BRD2, BRD3, BRD4, BRDT) in cancer models.
• Drug Discovery & Hit-to-Lead Optimization: Serves as a reference compound or starting point for developing novel therapeutic degraders with improved potency and selectivity.
• Mechanism of Action (MoA) Studies: Employed to validate BET proteins as drug targets and to understand downstream effects of their degradation.
• Biochemical and Cellular Assay Development: Used as a control or standard in high-throughput screening (HTS) and functional assays.
• Academic Research: Facilitates fundamental research in cell signaling, transcription, and chromatin biology.

Basic Information

Product Name	Protac Bet Degrader-2
CAS No.	2093388-33-9
Molecular Formula	C₄₄H₅₀ClN₇O₇
Molecular Weight	824.37 g/mol
Synonyms	PROTAC BET Degrader-2; BETd-260; MZ 1; (S,R,S)-AHPC-MeTEG-PEG4-CL1-BET; ARV-825 analog; dBET1; BRD4 Degrader; (S,R,S)-AHPC-PEG4-CL1-BET; PROTAC BRD4 Degrader-1
EINECS	Contact for details

Quality Control

Our Protac Bet Degrader-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing purity, chromatographic data, and spectroscopic results is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥95% (Area Percent)
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.