Description

2-Ethylbutyl ((R)-(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-Yl)-5-Cyano-3,4-Dihydroxytetrahydrofuran-2-Yl)Methoxy)(Phenoxy)Phosphoryl)-L-Alaninate is a sophisticated nucleotide analog prodrug, representing a critical advanced intermediate in modern pharmaceutical synthesis. Its complex structure is engineered to enhance bioavailability and target specificity for therapeutic nucleosides. This high-purity compound is essential for research and development laboratories and production facilities focused on next-generation antiviral and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Development: Used in R&D for prodrugs targeting viral polymerases, particularly in hepatitis and respiratory virus research.
• Oncology Research: Employed in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Prodrug Synthesis: The 2-ethylbutyl alaninate moiety is designed to improve the pharmacokinetic profile of active nucleoside metabolites.
• Biochemical Research: Utilized as a tool compound in enzymatic studies and mechanism-of-action investigations for nucleotide analogs.
• Process Chemistry & Scale-Up: A critical raw material for process development and cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	2-Ethylbutyl ((R)-(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-Yl)-5-Cyano-3,4-Dihydroxytetrahydrofuran-2-Yl)Methoxy)(Phenoxy)Phosphoryl)-L-Alaninate
CAS No.	2093124-26-4
Molecular Formula	C₂₈H₃₄N₇O₈P
Molecular Weight	627.59 g/mol
Synonyms	2-Ethylbutyl-L-alaninate phosphoramidate prodrug of a pyrrolotriazine nucleoside; (2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl methyl phenyl phosphoramidate 2-ethylbutyl-L-alaninate ester; Nucleoside Phosphoramidate Prodrug; Alaninate Prodrug Intermediate; Pyrrolotriazine Nucleoside Intermediate; Antiviral Nucleoside Analog Intermediate; Contact for additional trade names and identifiers.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity required for pharmaceutical applications. Our quality system includes in-process controls and comprehensive release testing. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles. We support development and commercial projects with specifications aligned with ICH guidelines and can supply material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. For long-term storage, consider desiccants or storage under nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.