Description

Fosmanogepix CAS NO 2091769-17-2 is a novel, investigational antifungal agent belonging to the class of Gwt1 inhibitors. This compound is of significant interest for its unique mechanism of action, targeting the inositol acylation step in fungal glycosylphosphatidylinositol (GPI) anchor biosynthesis. It is primarily sought by pharmaceutical research and development organizations engaged in the discovery and development of new therapeutic agents to combat invasive fungal infections, particularly those caused by resistant strains like Candida auris and Aspergillus species.

Application

• Pharmaceutical R&D: Core material for preclinical and clinical research into new systemic antifungal therapies.
• Mechanism of Action Studies: Used as a reference standard to study fungal GPI-anchored protein biosynthesis and inhibition.
• Antifungal Susceptibility Testing: Serves as a critical compound for in vitro testing against a broad spectrum of pathogenic fungi.
• Drug Combination Research: Investigated in combination with other antifungal agents to assess synergistic effects and overcome resistance.
• API Intermediate: Potential use as a key intermediate or starting material in the synthesis of related antifungal compounds.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medical mycology and drug discovery.

Basic Information

Product Name	Fosmanogepix
CAS No.	2091769-17-2
Molecular Formula	C23H22F3N5O6
Molecular Weight	521.45 g/mol
Synonyms	APX001; APX001A; E1211; Fosmanogepix (APX001); (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-{4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl dihydrogen phosphate; Manogepix fosfate
EINECS	Contact for details

Quality Control

Our Fosmanogepix is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.