Description

Guanosine, [P(R)]-2'-Deoxy-2'-Fluoro-5'-o-[(R)-Hydroxymercaptophosphinyl]-p-Thio-β-D-Arabino-Adenylyl-(3'→5')-3'-Deoxy-3'-Fluoro-, Cyclic Nucleotide is a sophisticated, high-purity modified cyclic dinucleotide analog designed for advanced biochemical research and therapeutic development. This compound is critical for studying and modulating intracellular signaling pathways, particularly those involving the cGAS-STING axis, which is a key target in immunology and oncology. It is an essential reagent for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on next-generation immunotherapies, antiviral agents, and precision medicine.

Application

• STING Agonist Research: A key tool compound for the investigation and development of stimulator of interferon genes (STING) pathway agonists for cancer immunotherapy.
• Immunology & Virology Studies: Used in fundamental research to understand innate immune responses against viral infections and to develop novel antiviral strategies.
• Pharmaceutical Development: Serves as a critical intermediate or active pharmaceutical ingredient (API) in the preclinical development of immunomodulatory drugs.
• Biochemical Assay Development: Employed as a standard or probe in high-throughput screening (HTS) assays to discover and validate new therapeutic compounds targeting nucleotide-sensing pathways.
• Cell Signaling Pathway Analysis: Utilized in mechanistic studies to dissect the downstream effects of cyclic dinucleotide signaling in various cell types.
• Nucleotide Chemistry & Prodrug Synthesis: Acts as a versatile building block for medicinal chemists synthesizing novel nucleotide prodrugs and analogs with enhanced stability and delivery properties.

Basic Information

Product Name	Guanosine, [P(R)]-2'-Deoxy-2'-Fluoro-5'-o-[(R)-Hydroxymercaptophosphinyl]-p-Thio-β-D-Arabino-Adenylyl-(3'→5')-3'-Deoxy-3'-Fluoro-, Cyclic Nucleotide
CAS No.	2082743-96-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2'3'-cGAMP Phosphorothioate Fluorinated Analog; Cyclic [G(2',5')pA(3',5')p] Phosphorothioate, 2'-Fluoro-2'-deoxy-3'-fluoro-3'-deoxy-; STING Agonist Nucleotide Analog; cGAS-STING Pathway Activator; Modified Cyclic Dinucleotide; Fluorinated cGAMP Derivative; Nucleotide-based Immunomodulator
EINECS	Contact for details

Quality Control

Our Guanosine, [P(R)]-2'-Deoxy-2'-Fluoro-5'-o-[(R)-Hydroxymercaptophosphinyl]-p-Thio-β-D-Arabino-Adenylyl-(3'→5')-3'-Deoxy-3'-Fluoro-, Cyclic Nucleotide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry-best practices and can support development projects requiring material manufactured under GMP guidelines for preclinical and clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.