Description

N2-iso-Buty Royl-5'-o-(4,4'-Dimethoxytrityl)-3'-Deoxy-3'-Fluoroguanosine is a sophisticated, high-purity nucleoside derivative designed for advanced research and pharmaceutical development. This compound is a critical building block in the synthesis of modified oligonucleotides, enabling the creation of novel therapeutic agents with enhanced stability and specificity. It is primarily utilized by research institutions and pharmaceutical companies specializing in antisense technology, siRNA development, and next-generation nucleic acid therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated nucleoside analogs for antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite monomer for introducing 3'-deoxy-3'-fluoro modifications into DNA/RNA strands, enhancing nuclease resistance.
• Antisense & siRNA Research: Used to develop stable, target-specific oligonucleotides for gene silencing and therapeutic applications.
• Proteomics & Diagnostics: Employed in the development of probes and primers for advanced diagnostic assays and molecular biology research.
• Bioconjugation: The dimethoxytrityl (DMT) protecting group allows for selective deprotection and further functionalization in complex synthetic pathways.

Basic Information

Product Name	N2-iso-Buty Royl-5'-o-(4,4'-Dimethoxytrityl)-3'-Deoxy-3'-Fluoroguanosine
CAS No.	2080404-19-7
Molecular Formula	C39H44FN5O7
Molecular Weight	713.81 g/mol
Synonyms	3'-Deoxy-3'-fluoro-N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)guanosine; 5'-O-DMT-3'-deoxy-3'-fluoro-N2-isobutyrylguanosine; 3'-Fluoro-3'-deoxy-N2-isobutyryl-5'-O-DMT-guanosine; N2-Isobutyryl-3'-deoxy-3'-fluoro-5'-O-(4,4'-dimethoxytrityl)guanosine; DMT-Fluoroguanosine Phosphoramidite Precursor; 3'-F-Guanosine Derivative; 2080404-19-7
EINECS	Contact for details

Quality Control

Every batch of N2-iso-Buty Royl-5'-o-(4,4'-Dimethoxytrityl)-3'-Deoxy-3'-Fluoroguanosine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity suitable for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.