Description

5-Methylcytosin-1-Yl-Acetic Acid Benzyl Ester is a high-purity, protected nucleoside derivative essential for advanced organic synthesis. This compound serves as a critical building block in the development of novel oligonucleotides and modified nucleic acids, enabling precise structural modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, molecular biology, and the synthesis of therapeutic agents targeting genetic pathways.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of modified nucleoside analogs with potential antiviral or anticancer activity.
• Oligonucleotide Synthesis: Used in solid-phase synthesis to incorporate 5-methylcytosine modifications into DNA or RNA strands for epigenetic research and therapeutic applications.
• Bioconjugation & Probe Development: Serves as a starting material for creating labeled nucleotides or probes used in diagnostics and bioanalytical assays.
• Academic & Industrial R&D: Employed in research exploring nucleic acid chemistry, gene silencing mechanisms, and the development of antisense oligonucleotides.
• Chemical Biology Tool: Facilitates the study of DNA-protein interactions and methylation processes through the introduction of specific cytosine modifications.

Basic Information

Product Name	5-Methylcytosin-1-Yl-Acetic Acid Benzyl Ester
CAS No.	2072152-18-0
Molecular Formula	C15H17N3O3
Molecular Weight	287.32 g/mol
Synonyms	1-(Benzyloxycarbonylmethyl)-5-methylcytosine; Benzyl 2-((5-Methyl-2-oxo-1,2-dihydropyrimidin-4-yl)amino)acetate; 5-Methylcytosine-1-acetic Acid Benzyl Ester; N1-(Carboxymethyl)-5-methylcytosine Benzyl Ester; 4-Amino-1-(benzyloxycarbonylmethyl)-5-methylpyrimidin-2(1H)-one; 5-Methyl-N1-(benzyloxycarbonylmethyl)cytosine; Protected 5-Methylcytosine Derivative
EINECS	Contact for details

Quality Control

Our 5-Methylcytosin-1-Yl-Acetic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.